European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. The annual incidence of new-onset LBBB was around 2.5%, and associated with a higher risk of adverse outcomes, highlighting the importance of repeat electrocardiogram review.Ĭ Identifier NCT0083658 (ATMOSPHERE) and NCT01035255 (PARADIGM-HF).Ĭ NCT01035255 NCT00853658.Ĭardiac resynchronization therapy Electrocardiography Heart failure Left bundle branch block Prognosis. In patients with HFrEF, a wide QRS was associated with worse clinical outcomes irrespective of morphology. Incident LBBB occurred in 495 (6.3%) patients (2.4 per 100 patient-years) and was associated with a higher risk of the primary composite outcome. A total of 1234 (15.6%) patients developed new-onset QRS widening ≥130 ms (6.1 per 100 patient-years). During a median follow-up of 2.5 years, the risk of the primary composite endpoint was higher among those with a wide QRS, irrespective of morphology: hazard ratios (95% confidence interval) LBBB 1.36 (1.23-1.50), RBBB 1.54 (1.31-1.79), non-specific IVCD 1.65 (1.40-1.94) and QRS 110-129 ms 1.35 (1.23-1.47), compared with QRS duration <110 ms. The risk of the primary composite outcome of cardiovascular death or heart failure hospitalization and all-cause mortality were estimated by use of Cox regression according to baseline QRS duration and morphology in 11 861 patients without an intracardiac device. We addressed these questions in the PARADIGM-HF and ATMOSPHERE trials. The importance of intra-ventricular conduction delay (IVCD), the incidence of new IVCD and its relationship to outcomes in heart failure and reduced ejection fraction (HFrEF) are not well studied. 10 Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX, USA and National Heart and Lung Institute, Imperial College, London.9 Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.8 Medical University of South Carolina and RHJ Department of Veterans Administration Medical Center, Charleston, SC, USA.7 Institut de Cardiologie, Université de Montréal, Montréal, Canada.6 Stavanger University Hospital, Stavanger, and the Institute of Internal Medicine, University of Bergen, Bergen, Norway.5 Cardiovascular Medicine, Brigham and Women's Hospital, Boston MA, USA.4 Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, USA.3 Division of Cardiology, Department of Medical Sciences, University of Turin, Turin, Italy.2 Department of Cardiology, Rigshospitalet University Hospital, Copenhagen, Denmark.1 BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
0 Comments
Leave a Reply. |